ERRO: Unable to instantiate application

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O projeto compila direitinho mas na hora da execução da o erro:

10-27 08:47:28.051: D/AndroidRuntime(5754): Shutting down VM
10-27 08:47:28.051: W/dalvikvm(5754): threadid=1: thread exiting with uncaught exception (group=0x41fcb2a0)
10-27 08:47:28.059: E/AndroidRuntime(5754): FATAL EXCEPTION: main
10-27 08:47:28.059: E/AndroidRuntime(5754): java.lang.RuntimeException: Unable to instantiate application br.gov.sp.artesp.sisf.mobile.SISFApplication: java.lang.ClassNotFoundException: br.gov.sp.artesp.sisf.mobile.SISFApplication
10-27 08:47:28.059: E/AndroidRuntime(5754): at android.app.LoadedApk.makeApplication(LoadedApk.java:501)
10-27 08:47:28.059: E/AndroidRuntime(5754): at android.app.ActivityThread.handleBindApplication(ActivityThread.java:4198)
10-27 08:47:28.059: E/AndroidRuntime(5754): at android.app.ActivityThread.access$1300(ActivityThread.java:140)
10-27 08:47:28.059: E/AndroidRuntime(5754): at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1288)
10-27 08:47:28.059: E/AndroidRuntime(5754): at android.os.Handler.dispatchMessage(Handler.java:99)
10-27 08:47:28.059: E/AndroidRuntime(5754): at android.os.Looper.loop(Looper.java:137)
10-27 08:47:28.059: E/AndroidRuntime(5754): at android.app.ActivityThread.main(ActivityThread.java:4895)
10-27 08:47:28.059: E/AndroidRuntime(5754): at java.lang.reflect.Method.invokeNative(Native Method)
10-27 08:47:28.059: E/AndroidRuntime(5754): at java.lang.reflect.Method.invoke(Method.java:511)
10-27 08:47:28.059: E/AndroidRuntime(5754): at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:994)
10-27 08:47:28.059: E/AndroidRuntime(5754): at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:761)
10-27 08:47:28.059: E/AndroidRuntime(5754): at dalvik.system.NativeStart.main(Native Method)
10-27 08:47:28.059: E/AndroidRuntime(5754): Caused by: java.lang.ClassNotFoundException: br.gov.sp.artesp.sisf.mobile.SISFApplication
10-27 08:47:28.059: E/AndroidRuntime(5754): at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:61)
10-27 08:47:28.059: E/AndroidRuntime(5754): at java.lang.ClassLoader.loadClass(ClassLoader.java:501)
10-27 08:47:28.059: E/AndroidRuntime(5754): at java.lang.ClassLoader.loadClass(ClassLoader.java:461)
10-27 08:47:28.059: E/AndroidRuntime(5754): at android.app.Instrumentation.newApplication(Instrumentation.java:982)
10-27 08:47:28.059: E/AndroidRuntime(5754): at android.app.LoadedApk.makeApplication(LoadedApk.java:496)
10-27 08:47:28.059: E/AndroidRuntime(5754): ... 11 more